The sibling comparison's matched analysis estimates the effect of exposure in discordant twin pairs, and equals a family-level effect only if structural additivity and non-differential interference hold, as in a cross-over trial.
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Causal interpretation of the sibling comparison and its relation to the cross-over design
The sibling comparison's matched analysis estimates the effect of exposure in discordant twin pairs, and equals a family-level effect only if structural additivity and non-differential interference hold, as in a cross-over trial.