An unsupervised deep-clustering vocabulary of liver MRI patches separated NASH treatment groups better than fat fraction and ALT and predicted biopsy grades, with replication in a second cohort.
Discriminatively Boosted Image Clustering with Fully Convolutional Auto-Encoders
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abstract
Traditional image clustering methods take a two-step approach, feature learning and clustering, sequentially. However, recent research results demonstrated that combining the separated phases in a unified framework and training them jointly can achieve a better performance. In this paper, we first introduce fully convolutional auto-encoders for image feature learning and then propose a unified clustering framework to learn image representations and cluster centers jointly based on a fully convolutional auto-encoder and soft $k$-means scores. At initial stages of the learning procedure, the representations extracted from the auto-encoder may not be very discriminative for latter clustering. We address this issue by adopting a boosted discriminative distribution, where high score assignments are highlighted and low score ones are de-emphasized. With the gradually boosted discrimination, clustering assignment scores are discriminated and cluster purities are enlarged. Experiments on several vision benchmark datasets show that our methods can achieve a state-of-the-art performance.
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Identifying Signatures of Image Phenotypes to Track Treatment Response in Liver Disease
An unsupervised deep-clustering vocabulary of liver MRI patches separated NASH treatment groups better than fat fraction and ALT and predicted biopsy grades, with replication in a second cohort.