Neutralization titers follow Gumbel distributions indicating influenza polyclonal responses are either collective or dominated by few strong binders, captured quantitatively by an equilibrium binding model.
(2022) A biophysical model of viral escape from polyclonal antibodies.Virus Evolution8:veac110
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Neutralization titers reveal the structure of polyclonal antibody responses
Neutralization titers follow Gumbel distributions indicating influenza polyclonal responses are either collective or dominated by few strong binders, captured quantitatively by an equilibrium binding model.