A dual-decoder variational autoencoder reconstructs single-cell Raman spectra from brightfield images with ~98% cosine similarity and discriminates bacterial transgenic states at 88% accuracy.
Each raw image was loaded and smoothed using a Gaussian filter to suppress high-frequency noise while preserving cell boundaries
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physics.optics 1years
2026 1verdicts
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Pic2Spec: Generative Modeling Reconstructs Single Cell Raman Fingerprints from Brightfield Images
A dual-decoder variational autoencoder reconstructs single-cell Raman spectra from brightfield images with ~98% cosine similarity and discriminates bacterial transgenic states at 88% accuracy.