FLASH sparing of toxicity increases for serial organs (low n in LKB model) compared to parallel organs when dose distributions are inhomogeneous and the effect is local.
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Simulations indicate radiolytic oxygen depletion produces lower tumor control probability for FLASH-RT than CONV-RT despite iso-effective preclinical tumor volume curves.
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Effect of the dose distribution and organ architecture on the toxicity in FLASH radiotherapy: a modeling study
FLASH sparing of toxicity increases for serial organs (low n in LKB model) compared to parallel organs when dose distributions are inhomogeneous and the effect is local.
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An in-silico study of conventional and FLASH radiotherapy iso-effectiveness: Radiolytic oxygen depletion and its potential impact on tumor control probability
Simulations indicate radiolytic oxygen depletion produces lower tumor control probability for FLASH-RT than CONV-RT despite iso-effective preclinical tumor volume curves.