DeepFilters jointly optimizes a parameterized pupil filter and digital reconstruction network via a calibrated differentiable forward model with empirical scattering kernels to extend PSF depth from 16 to over 400 microns in clear media and recover signals beyond 120 microns in tissues.
A miniaturized mesoscope for the large-scale single-neuron-resolved imaging of neuronal activity in freely behaving mice
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2026 1verdicts
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DeepFilters: Scattering-Aware Pupil Engineering with Learned Digital Filter Reconstruction for Extended Depth of Field Microscopy
DeepFilters jointly optimizes a parameterized pupil filter and digital reconstruction network via a calibrated differentiable forward model with empirical scattering kernels to extend PSF depth from 16 to over 400 microns in clear media and recover signals beyond 120 microns in tissues.