Neutralization titers follow Gumbel distributions indicating influenza polyclonal responses are either collective or dominated by few strong binders, captured quantitatively by an equilibrium binding model.
(2015) Salmonella infection drives promiscuous b cell activation followed by extrafollicular affinity maturation.Immunity43:120–131
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Neutralization titers reveal the structure of polyclonal antibody responses
Neutralization titers follow Gumbel distributions indicating influenza polyclonal responses are either collective or dominated by few strong binders, captured quantitatively by an equilibrium binding model.