Disordered regions are common in ProteinGym and consistently degrade zero-shot fitness prediction across model classes, while simple multi-modal ensembles remain the strongest baselines.
Blaabjerg, Nicolas Jonsson, Wouter Boomsma, Amelie Stein, and Kresten Lindorff-Larsen
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Exploring zero-shot structure-based protein fitness prediction
Disordered regions are common in ProteinGym and consistently degrade zero-shot fitness prediction across model classes, while simple multi-modal ensembles remain the strongest baselines.