A two-stage intra-patient curve-free Bayesian decision-theoretic design for dose escalation under nonincreasing cycle-specific toxicity.
/ for dose level ๐ in cycle ๐. In the dependent setting, if a patient experiences a DLT in cycle ๐โ1, then the toxicity probability in cycle ๐ is increased to ๐
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TWICEBEE: A Two-stage Intra-patient Curve-free Bayesian Decision-Theoretic Dose Escalation Design
A two-stage intra-patient curve-free Bayesian decision-theoretic design for dose escalation under nonincreasing cycle-specific toxicity.