HESCAPE shows that cross-modal contrastive pretraining helps mutation classification but hurts gene expression prediction in spatial transcriptomics, implicating batch effects.
Schoenfeld, and Chad Vanderbilt
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A Large-Scale Benchmark of Cross-Modal Learning for Histology and Gene Expression in Spatial Transcriptomics
HESCAPE shows that cross-modal contrastive pretraining helps mutation classification but hurts gene expression prediction in spatial transcriptomics, implicating batch effects.