In 2-period cluster randomized crossover trials with informative sizes, independence estimating equations always target the intended average treatment effect estimands, while nested exchangeable mixed model estimators do not.
Reporting of cluster randomised crossover trials: ex- tension of the CONSORT 2010 statement with explanation and elaboration.BMJ.2025:e080472
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What is estimated in cluster randomized crossover trials with informative sizes? -- A survey of estimands and common estimators
In 2-period cluster randomized crossover trials with informative sizes, independence estimating equations always target the intended average treatment effect estimands, while nested exchangeable mixed model estimators do not.