An integro-differential model with continuous phenotypic plasticity shows adaptive therapy outperforms continuous regimens by exploiting competition between sensitive and resistant clones, with high plasticity accelerating relapse under fixed therapy.
Single-cell lineages reveal the rates, routes, and drivers of metastasis in cancer xenografts.Science, 371(6532), Feb 2021
1 Pith paper cite this work. Polarity classification is still indexing.
1
Pith paper citing it
fields
q-bio.PE 1years
2026 1verdicts
UNVERDICTED 1representative citing papers
citing papers explorer
-
Modeling tumor cell heterogeneity and plasticity in adaptive therapy
An integro-differential model with continuous phenotypic plasticity shows adaptive therapy outperforms continuous regimens by exploiting competition between sensitive and resistant clones, with high plasticity accelerating relapse under fixed therapy.