An iterative leveling algorithm constructs detailed-balance equilibrium concentrations for athermic monomer-polymer systems, exponentially suppressing off-target species, and applies this to bound leak in DNA circuits.
How far is complex balancing from detailed balancing? Bulletin of mathematical biology , 73(4):811--828, 2011
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Computing and Bounding Equilibrium Concentrations in Athermic Chemical Systems
An iterative leveling algorithm constructs detailed-balance equilibrium concentrations for athermic monomer-polymer systems, exponentially suppressing off-target species, and applies this to bound leak in DNA circuits.