B²-FIC calibrates Bayesian phase-II borrowing for type I error, then uses IA1 predictive probability to schedule the earliest admissible IA2, yielding earlier decisions than fixed GSD when evidence is favorable while holding empirical FWER near 0.025.
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A Bayesian predictive framework for adaptive interim-analysis timing with robust borrowing in confirmatory trials
B²-FIC calibrates Bayesian phase-II borrowing for type I error, then uses IA1 predictive probability to schedule the earliest admissible IA2, yielding earlier decisions than fixed GSD when evidence is favorable while holding empirical FWER near 0.025.