IFM conditions flow-matching velocity fields on patient history and planned treatments, using velocity-field Jacobian regularization to enforce signed, dose-bounded insulin-lowering and carbohydrate-raising effects on glucose in simulated UVA/Padova type 1 diabetes data.
Causal Regularization
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abstract
In application domains such as healthcare, we want accurate predictive models that are also causally interpretable. In pursuit of such models, we propose a causal regularizer to steer predictive models towards causally-interpretable solutions and theoretically study its properties. In a large-scale analysis of Electronic Health Records (EHR), our causally-regularized model outperforms its L1-regularized counterpart in causal accuracy and is competitive in predictive performance. We perform non-linear causality analysis by causally regularizing a special neural network architecture. We also show that the proposed causal regularizer can be used together with neural representation learning algorithms to yield up to 20% improvement over multilayer perceptron in detecting multivariate causation, a situation common in healthcare, where many causal factors should occur simultaneously to have an effect on the target variable.
fields
cs.LG 1years
2026 1verdicts
UNVERDICTED 1representative citing papers
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Interventional Flow Matching: Prospective Dose-Response Forecasting with Velocity-Field Jacobian Regularization
IFM conditions flow-matching velocity fields on patient history and planned treatments, using velocity-field Jacobian regularization to enforce signed, dose-bounded insulin-lowering and carbohydrate-raising effects on glucose in simulated UVA/Padova type 1 diabetes data.