Causal analysis yields 3.40% absolute risk reduction from 20 mmHg SBP drop versus 4.14% observational estimate, indicating 21.8% overestimation.
Metalearners for estimating heterogeneous treatment effects using machine learning.Proc Natl Acad Sci USA.2019;116(10):4156–4165
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Causal Inference of Blood Pressure Reduction and Coronary Heart Disease Risk in the Framingham Study
Causal analysis yields 3.40% absolute risk reduction from 20 mmHg SBP drop versus 4.14% observational estimate, indicating 21.8% overestimation.