A new closed-book, sequence-only benchmark, EpiBench, measures epitope reasoning in LLMs and finds them near chance on residue-level localization and escape assessment, with only coarse region-level signal.
Flip: Benchmark tasks in fitness landscape inference for proteins.bioRxiv, pp
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EpiBench: Can LLMs Understand Epitopes for Antibody Drug Discovery?
A new closed-book, sequence-only benchmark, EpiBench, measures epitope reasoning in LLMs and finds them near chance on residue-level localization and escape assessment, with only coarse region-level signal.