CellxPert uses inference-time MCMC steering on a multi-omics single-cell foundation model to predict genome-wide transcriptomic responses to gene perturbations and outperforms baselines on cell-type annotation, perturbation prediction, and multi-omic integration benchmarks.
If [CLS] is enabled, we set gc,1=V , bc,1=0 (neutral bin), shift the original pairs by one, and take L=G+1 (otherwise L=G)
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CellxPert: Inference-Time MCMC Steering of a Multi-Omics Single-Cell Foundation Model for In-Silico Perturbation
CellxPert uses inference-time MCMC steering on a multi-omics single-cell foundation model to predict genome-wide transcriptomic responses to gene perturbations and outperforms baselines on cell-type annotation, perturbation prediction, and multi-omic integration benchmarks.