DoMinO reformulates discrete flow matching sampling as an MDP for unbiased RL fine-tuning with new TV regularizers, yielding better enhancer activity and naturalness on DNA design tasks.
Regulatory dna sequence design with rein- forcement learning.arXiv preprint arXiv:2503.07981
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Discrete Flow Matching Policy Optimization
DoMinO reformulates discrete flow matching sampling as an MDP for unbiased RL fine-tuning with new TV regularizers, yielding better enhancer activity and naturalness on DNA design tasks.