MD simulations show TDP-43 multidomain structure and polyA RNA binding modulate intermolecular interactions, with RRMs increasing viscosity, NTD decreasing it, and RNA boosting elasticity in phase-separated condensates.
Elbaum-Garfinkle, Y
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TDP-43 multidomains and RNA modulate interactions and viscoelasticity in biomolecular condensates
MD simulations show TDP-43 multidomain structure and polyA RNA binding modulate intermolecular interactions, with RRMs increasing viscosity, NTD decreasing it, and RNA boosting elasticity in phase-separated condensates.