A Bayesian multi-study NMF with a probit mixture prior estimates subject-level mutational signature presence, prevalence per cancer type, and covariate effects, with a fast variational algorithm and an R package.
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Bayesian Probit Multi-Study Non-negative Matrix Factorization for Mutational Signatures
A Bayesian multi-study NMF with a probit mixture prior estimates subject-level mutational signature presence, prevalence per cancer type, and covariate effects, with a fast variational algorithm and an R package.