COPD exacerbation rates in placebo arms of clinical trials declined by roughly 6.7% per year, or 50% per decade, between the late 1990s and 2019.
Global Strategy for the Diagnosis, Management, and Prevention of Chronic Obstructive Lung Disease 2017 Report
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Decline of COPD exacerbations in clinical trials over two decades -- a systematic review and meta-regression
COPD exacerbation rates in placebo arms of clinical trials declined by roughly 6.7% per year, or 50% per decade, between the late 1990s and 2019.