Maximum likelihood fitting of distance-dependent turning probabilities to cell trajectories recovers true interaction parameters even when migration behavior switches over time, unlike force-based models.
Cancer immunotherapy
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2019 2verdicts
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A p-value distribution test, validated on simulations of chemotactic mechanisms, distinguishes target-directed cell migration from blind random movement by comparison to randomized-target null models.
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Inferring long-range interactions between immune and tumor cells -- pitfalls and (partial) solutions
Maximum likelihood fitting of distance-dependent turning probabilities to cell trajectories recovers true interaction parameters even when migration behavior switches over time, unlike force-based models.
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Detecting long-range attraction between migrating cells based on p-value distributions
A p-value distribution test, validated on simulations of chemotactic mechanisms, distinguishes target-directed cell migration from blind random movement by comparison to randomized-target null models.