Combinatorial Benders decomposition with MIS cuts is the fastest tested method for ll-FBA, solving 93% of BiGG instances within 1800 seconds.
Beard, Eric Babson, Edward Curtis, and Hong Qian
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Mixed-Integer Optimization for Loopless Flux Distributions in Metabolic Networks
Combinatorial Benders decomposition with MIS cuts is the fastest tested method for ll-FBA, solving 93% of BiGG instances within 1800 seconds.