B²-FIC calibrates Bayesian phase-II borrowing for type I error, then uses IA1 predictive probability to schedule the earliest admissible IA2, yielding earlier decisions than fixed GSD when evidence is favorable while holding empirical FWER near 0.025.
Robust time selection for interim analysis in the Bayesian phase 2 exploratory clinical trial.Journal of Biopharmaceutical Statistics.2024;34(3):413–423
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A Bayesian predictive framework for adaptive interim-analysis timing with robust borrowing in confirmatory trials
B²-FIC calibrates Bayesian phase-II borrowing for type I error, then uses IA1 predictive probability to schedule the earliest admissible IA2, yielding earlier decisions than fixed GSD when evidence is favorable while holding empirical FWER near 0.025.