RISE uses rank-based nonparametric screening plus sample splitting to build a weighted gene-expression signature that approximates the vaccine's effect on antibody response.
Innovative trial designs and analyses for vaccine clinical development
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RISE: Two-Stage Rank-Based Identification of High-Dimensional Surrogate Markers Applied to Vaccinology
RISE uses rank-based nonparametric screening plus sample splitting to build a weighted gene-expression signature that approximates the vaccine's effect on antibody response.