In IDH-wildtype glioblastoma, higher MAPK pathway activity reproducibly associates with lower PPOX expression, relocating the proposed mechanism of reduced 5-ALA fluorescence from clearance to synthesis.
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MAPK Pathway Activity and Heme Biosynthesis Gene Expression in IDH-Wildtype Glioblastoma: A Purity-Adjusted, Discovery-Validation Analysis
In IDH-wildtype glioblastoma, higher MAPK pathway activity reproducibly associates with lower PPOX expression, relocating the proposed mechanism of reduced 5-ALA fluorescence from clearance to synthesis.