Causal analysis yields 3.40% absolute risk reduction from 20 mmHg SBP drop versus 4.14% observational estimate, indicating 21.8% overestimation.
A randomized trial of intensive versus standard blood-pressure control.N Engl J Med.2015;373(22):2103–2116
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Causal Inference of Blood Pressure Reduction and Coronary Heart Disease Risk in the Framingham Study
Causal analysis yields 3.40% absolute risk reduction from 20 mmHg SBP drop versus 4.14% observational estimate, indicating 21.8% overestimation.