Neutralization titers follow Gumbel distributions indicating influenza polyclonal responses are either collective or dominated by few strong binders, captured quantitatively by an equilibrium binding model.
(2016) Molecular-level analysis of the serum antibody repertoire in young adults before and after sea- sonal influenza vaccination.Nature Medicine22:1456– 1464
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Neutralization titers reveal the structure of polyclonal antibody responses
Neutralization titers follow Gumbel distributions indicating influenza polyclonal responses are either collective or dominated by few strong binders, captured quantitatively by an equilibrium binding model.