A perspective contends that a model's scientific value comes from constrained parameters and analyzed dynamics, not from component count; whole-cell simulations currently reproduce data without delivering mechanistic insight.
Karr, Jayodita C
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Simulating is not always understanding: When model complexity obscures biology
A perspective contends that a model's scientific value comes from constrained parameters and analyzed dynamics, not from component count; whole-cell simulations currently reproduce data without delivering mechanistic insight.