A comprehensive review supports a two-stage model in which psychedelics first increase neural sensitivity (meta-plasticity) and then drive lasting structural changes (hyper-plasticity), but it also highlights the wide gap between strong animal evidence and weak human evidence.
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Neuroplasticity and Psychedelics: a comprehensive examination of classic and non-classic compounds in pre and clinical models
A comprehensive review supports a two-stage model in which psychedelics first increase neural sensitivity (meta-plasticity) and then drive lasting structural changes (hyper-plasticity), but it also highlights the wide gap between strong animal evidence and weak human evidence.