LineageFlow generates family-aware protein sequences via flow matching from ancestral sequence reconstruction priors, achieving near-natural family validity and improved structural confidence with a rerouting technique for guided sampling.
Nucleic Acids Research , year=
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LineageFlow: Flow Matching for High-Fidelity Family-Aware Protein Sequence Generation
LineageFlow generates family-aware protein sequences via flow matching from ancestral sequence reconstruction priors, achieving near-natural family validity and improved structural confidence with a rerouting technique for guided sampling.