GeoSAE extracts a compact, interpretable feature set from frozen brain MRI foundation models that predicts MCI-to-AD conversion (AUC 0.746) with age-deconfounded annotations and replicates across cohorts.
Identification of causal effects of neuroanatomy on cognitive decline requires modeling un- observed confounders.Alzheimer’s & Dementia, 19(5):1994– 2005
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GeoSAE: Geometric Prior-Guided Layer-Wise Sparse Autoencoder Annotation of Brain MRI Foundation Models
GeoSAE extracts a compact, interpretable feature set from frozen brain MRI foundation models that predicts MCI-to-AD conversion (AUC 0.746) with age-deconfounded annotations and replicates across cohorts.