ProMORNA uses a BART encoder-decoder pretrained on millions of protein-mRNA pairs followed by multi-objective group relative policy optimization to generate full-length mRNA sequences that improve predicted half-life and translation efficiency over supervised baselines on an unseen luciferase target
mRNA-GPT: A generative model for full-length mRNA design and optimization.bioRxiv, page 2026.03.31.715707
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Protein-Conditioned Multi-Objective Reinforcement Learning for Full-Length mRNA Design
ProMORNA uses a BART encoder-decoder pretrained on millions of protein-mRNA pairs followed by multi-objective group relative policy optimization to generate full-length mRNA sequences that improve predicted half-life and translation efficiency over supervised baselines on an unseen luciferase target