RNA-FM embeddings, fed into a lightweight CNN with binarized ATAC-seq accessibility labels, outperform published Cas12 gRNA activity baselines on the Kim et al. HT1 test set.
Pre-trained language models for biological sequences at the scale of the human genome
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Multimodal Modeling of CRISPR-Cas12 Activity Using Foundation Models and Chromatin Accessibility Data
RNA-FM embeddings, fed into a lightweight CNN with binarized ATAC-seq accessibility labels, outperform published Cas12 gRNA activity baselines on the Kim et al. HT1 test set.