An integro-differential model with continuous phenotypic plasticity shows adaptive therapy outperforms continuous regimens by exploiting competition between sensitive and resistant clones, with high plasticity accelerating relapse under fixed therapy.
Activity and safety of kees - an oral multi-drug chemo-hormonal metronomic combination regimen in metastatic castration-resistant prostate cancer.BMC Cancer, 23(1), April 2023
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Modeling tumor cell heterogeneity and plasticity in adaptive therapy
An integro-differential model with continuous phenotypic plasticity shows adaptive therapy outperforms continuous regimens by exploiting competition between sensitive and resistant clones, with high plasticity accelerating relapse under fixed therapy.