Evo2 learns local CTCF grammar but fails to capture higher-order 3D chromatin structure in tests on TADs and convergent loops.
CRISPR Inversion of CTCF Sites Alters Genome Topology and Enhancer/Promoter Function.Cell, 162(4):900–910, 2015
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Probing 3D Chromatin Structure Awareness in Evo2 DNA Language Model
Evo2 learns local CTCF grammar but fails to capture higher-order 3D chromatin structure in tests on TADs and convergent loops.