Noise-driven switching between expression basins in frustrated genes, locked by slow epigenetic feedback, produces robust input-dependent differentiation with logarithmic time dependence on noise strength.
Kaneko, Evolution of robustness to noise and mu- tation in gene expression dynamics, PLoS one2, e434 (2007)
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Noise-Driven Differentiation via Gene Frustration and Epigenetic Fixation
Noise-driven switching between expression basins in frustrated genes, locked by slow epigenetic feedback, produces robust input-dependent differentiation with logarithmic time dependence on noise strength.