The P23T mutation does not produce a consistent increase in γD-crystallin surface hydrophobicity, and hydrophobic-effect models require finely tuned parameters to invert solubility, so microscopic support for the hydrophobic mechanism is weak.
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Using schematic models to understand the microscopic basis for inverted solubility in $\gamma$D-crystallin
The P23T mutation does not produce a consistent increase in γD-crystallin surface hydrophobicity, and hydrophobic-effect models require finely tuned parameters to invert solubility, so microscopic support for the hydrophobic mechanism is weak.