A docking paper claims a two-plant-compound combination binds BCL-2 and AKT-1 more strongly than venetoclax or melatonin, but the comparison is not apples-to-apples.
Synthesis of Mechanism for single- and hybrid-tasks using Differential Evolution
1 Pith paper cite this work. Polarity classification is still indexing.
abstract
The optimal dimensional synthesis for planar mechanisms using differential evolution (DE) is demonstrated. Four examples are included: in the first case, the synthesis of a mechanism for hybrid-tasks, considering path generation, function generation, and motion generation, is carried out. The second and third cases pertain to path generation, with and without prescribed timing. Finally, the synthesis of an Ackerman mechanism is reported. Order defect problem is solved by manipulating individuals instead of penalizing or discretizing the search space for the parameters. A technique that consists in applying a transformation in order to satisfy the Grashof and crank conditions to generate an initial elitist population is introduced. As a result, the evolutionary algorithm increases its efficiency.
fields
q-bio.BM 1years
2025 1verdicts
REJECT 1representative citing papers
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Computational Analysis using Multi-ligand Simultaneous Docking of Withaferin A and Garcinol Reveals Enhanced BCL-2 and AKT-1 Inhibition
A docking paper claims a two-plant-compound combination binds BCL-2 and AKT-1 more strongly than venetoclax or melatonin, but the comparison is not apples-to-apples.