StateXDiff integrates transcriptomic profiles with inferred protein features via a conditional diffusion model and mechanism-aware drug templates to predict single-cell drug perturbation responses under unseen cell lines, drugs, and combinatorial settings.
The cardiac glycoside convallatoxin inhibits the growth of colorectal cancer cells in a p53-independent manner.Molecular genetics and metabolism reports, 13:42–45, 2017
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StateXDiff: Cell State-Contextualized Multimodal Diffusion for Single-Cell Perturbation Prediction
StateXDiff integrates transcriptomic profiles with inferred protein features via a conditional diffusion model and mechanism-aware drug templates to predict single-cell drug perturbation responses under unseen cell lines, drugs, and combinatorial settings.