DPLM-Evo adds explicit edit operations and a latent alignment space to discrete diffusion protein models, achieving SOTA single-sequence mutation effect prediction on ProteinGym while supporting variable-length generation.
Diffuser: Diffusion via edit-based reconstruction
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Towards A Generative Protein Evolution Machine with DPLM-Evo
DPLM-Evo adds explicit edit operations and a latent alignment space to discrete diffusion protein models, achieving SOTA single-sequence mutation effect prediction on ProteinGym while supporting variable-length generation.