A-CODE presents a fully atomic one-stage multimodal diffusion model for protein co-design that claims superior unconditional generation performance over prior one- and two-stage models plus a tenfold success-rate gain on hard binder-design tasks.
Mixed citations
Robust deep learning–based protein sequence design using proteinmpnn.Science, 378(6615):49–56
Mixed citation behavior. Most common role is background (67%).
7
Pith papers citing it
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67% of classified citations
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background 4
method 2
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years
2026 7representative citing papers
Defines Conditional Distribution Matching (CDM) as finding inputs whose induced conditional distributions match a target distribution and proposes the MLGD-F inference-time algorithm using pretrained diffusion models to solve it without retraining.
VibeProteinBench is a new benchmark evaluating LLMs on open-ended language-interfaced protein design across recognition, engineering, and generation, with no model showing strong performance in all areas.
Yeti is a compact tokenizer for protein structures that delivers strong codebook use, token diversity, and reconstruction while enabling from-scratch multimodal generation of plausible sequences and structures with 10x fewer parameters than ESM3.
SGRPO is a GRPO-style framework that constructs set-level diversity rewards via supergroup sampling and leave-one-out redistribution to expand the utility-diversity Pareto frontier in biomolecular design tasks.
RIDER improves RNA 3D structural similarity by over 100% using RL-guided diffusion and discovers non-native sequence designs.
MolClaw deploys a hierarchical skill architecture to reach state-of-the-art results on a new benchmark of multi-step drug discovery tasks.
citing papers explorer
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A-CODE: Fully Atomic Protein Co-Design with Unified Multimodal Diffusion
A-CODE presents a fully atomic one-stage multimodal diffusion model for protein co-design that claims superior unconditional generation performance over prior one- and two-stage models plus a tenfold success-rate gain on hard binder-design tasks.
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Inverse Design for Conditional Distribution Matching
Defines Conditional Distribution Matching (CDM) as finding inputs whose induced conditional distributions match a target distribution and proposes the MLGD-F inference-time algorithm using pretrained diffusion models to solve it without retraining.
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VibeProteinBench: An Evaluation Benchmark for Language-interfaced Vibe Protein Design
VibeProteinBench is a new benchmark evaluating LLMs on open-ended language-interfaced protein design across recognition, engineering, and generation, with no model showing strong performance in all areas.
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Yeti: A compact protein structure tokenizer for reconstruction and multi-modal generation
Yeti is a compact tokenizer for protein structures that delivers strong codebook use, token diversity, and reconstruction while enabling from-scratch multimodal generation of plausible sequences and structures with 10x fewer parameters than ESM3.
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Pushing Biomolecular Utility-Diversity Frontiers with Supergroup Relative Policy Optimization
SGRPO is a GRPO-style framework that constructs set-level diversity rewards via supergroup sampling and leave-one-out redistribution to expand the utility-diversity Pareto frontier in biomolecular design tasks.
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RIDER: 3D RNA Inverse Design with Reinforcement Learning-Guided Diffusion
RIDER improves RNA 3D structural similarity by over 100% using RL-guided diffusion and discovers non-native sequence designs.
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MolClaw: An Autonomous Agent with Hierarchical Skills for Drug Molecule Evaluation, Screening, and Optimization
MolClaw deploys a hierarchical skill architecture to reach state-of-the-art results on a new benchmark of multi-step drug discovery tasks.