Sesame uses flow matching to turn apo protein backbones into holo-like backbones, outperforming a Schrödinger-bridge baseline on geometric benchmarks but with limited docking validation.
Holo-like and druggable protein conformations from enhanced sampling of binding pocket volume and shape
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Sesame: Opening the door to protein pockets
Sesame uses flow matching to turn apo protein backbones into holo-like backbones, outperforming a Schrödinger-bridge baseline on geometric benchmarks but with limited docking validation.