By fitting a TAD-based DSB classification model to cell survival curves, the authors find that per-event lethality is highest for DSBs in frequently interacting TADs, intermediate for clustered DSBs in one TAD, and lowest for isolated DSBs.
‘Survival’: a simulation toolkit introducing a Correlation between Damage in 3D Genome and Cell Death 17 modular approach for radiobiological evaluations in ion beam therapy
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Correlation Between DNA Double-Strand Break Distribution in 3D Genome and Radiation-Induced Cell Death
By fitting a TAD-based DSB classification model to cell survival curves, the authors find that per-event lethality is highest for DSBs in frequently interacting TADs, intermediate for clustered DSBs in one TAD, and lowest for isolated DSBs.