Using an LLM to select biologically similar neighbor drugs and averaging their measured effects improves zero-shot prediction of molecular perturbation responses, particularly for unseen cell lines.
Predicting cellular responses to complex perturbations in high‐throughput screens
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LLM-Guided Retrieval for Prediction of Molecular Perturbation Responses
Using an LLM to select biologically similar neighbor drugs and averaging their measured effects improves zero-shot prediction of molecular perturbation responses, particularly for unseen cell lines.