Germline-absorbing discrete diffusion uses the germline sequence as the absorbing state to reduce germline bias in antibody modeling, raising non-germline residue prediction accuracy from 26% to 46% and improving conditional generation tradeoffs over EvoProtGrad.
FDA approves 100th monoclonal antibody product.Nature Reviews Drug Discovery, 20(7):491–495, 2021
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Conditional generation of antibody sequences with classifier-guided germline-absorbing discrete diffusion
Germline-absorbing discrete diffusion uses the germline sequence as the absorbing state to reduce germline bias in antibody modeling, raising non-germline residue prediction accuracy from 26% to 46% and improving conditional generation tradeoffs over EvoProtGrad.