RosettaSearch applies LLM-driven multi-objective search at inference time to improve backbone-conditioned protein sequences, recovering designs with 18-68% better structural fidelity and 2.5x higher success rates than single-pass models like LigandMPNN.
Reprompting: Automated chain-of-thought prompt inference through gibbs sampling.arXiv preprint arXiv:2305.09993
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Proposes compiling preference pairs into readable natural-language specifications for inference-time LLM alignment, claiming outperformance over DPO on dense-preference domains.
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RosettaSearch: Multi-Objective Inference-Time Search for Protein Sequence Design
RosettaSearch applies LLM-driven multi-objective search at inference time to improve backbone-conditioned protein sequences, recovering designs with 18-68% better structural fidelity and 2.5x higher success rates than single-pass models like LigandMPNN.
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Towards Spec Learning: Inference-Time Alignment from Preference Pairs
Proposes compiling preference pairs into readable natural-language specifications for inference-time LLM alignment, claiming outperformance over DPO on dense-preference domains.