EBMs trained with non-persistent short runs reproduce empirical data statistics via a precise dynamical process, not the equilibrium measure.
C., Zecchina, R., and Berg, J
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The paper shows that quasi-linkage equilibrium persists at low migration rates between two populations and provides analytical inference relations for estimating additive fitness and epistatic interactions from whole-genome time-series data.
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Explaining the effects of non-convergent sampling in the training of Energy-Based Models
EBMs trained with non-persistent short runs reproduce empirical data statistics via a precise dynamical process, not the equilibrium measure.
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Fitness Inference in Presence of Migrations between Coupled Evolving Populations
The paper shows that quasi-linkage equilibrium persists at low migration rates between two populations and provides analytical inference relations for estimating additive fitness and epistatic interactions from whole-genome time-series data.