Full-chain structural novelty is not evidence of fold invention, because generated backbones mostly contain known domains and a zero-training retrieval baseline reproduces the same novelty profile.
Nature structural biology , volume=
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Is Retrieval All You Need? Assessment and Emergence of Novelty in Protein Structure Generation
Full-chain structural novelty is not evidence of fold invention, because generated backbones mostly contain known domains and a zero-training retrieval baseline reproduces the same novelty profile.